DNA Damage Responses: Mechanisms and Roles in Human Disease
نویسندگان
چکیده
منابع مشابه
DNA Damage Responses: Mechanisms and Roles in Human Disease
Significant progress has been made in recent years in elucidating the molecular controls of cellular responses to DNA damage in mammalian cells. Much of our understanding of the mechanisms involved in cellular DNA damage response pathways has come from studies of human cancer susceptibility syndromes that are altered in DNA damage responses. Ataxia-telangiectasia mutated (ATM), the gene mutated...
متن کاملDNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.
Significant progress has been made in recent years in elucidating the molecular controls of cellular responses to DNA damage in mammalian cells. Much of our understanding of the mechanisms involved in cellular DNA damage response pathways has come from studies of human cancer susceptibility syndromes that are altered in DNA damage responses. Ataxia-telangiectasia mutated (ATM), the gene mutated...
متن کاملOxidative DNA damage: mechanisms, mutation, and disease.
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2'deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to th...
متن کاملDistinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
The cellular response to DNA double-strand breaks involves direct activation of ataxia telangiectasia mutated (ATM) and indirect activation of ataxia telangiectasia and Rad3 related (ATR) in an ATM/Mre11/cell-cycle-dependent manner. Here, we report that the crucial checkpoint signalling proteins-p53, structural maintainance of chromosomes 1 (SMC1), p53 binding protein 1 (53BP1), checkpoint kina...
متن کاملDNA Damage and Oxidative Stress in Human Disease
1 Medical Genetics Service, Hospital de Cĺınicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035-903 Porto Alegre, RS, Brazil 2 PPG Ciências Farmacêiticas, Universidade Federal do Piauı́, 64049-550 Terezina, PI, Brazil 3 Genetics Service, Hospital Universitário, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil 4 PPG BioSaúde, Universidade Luterana do Brasil, Avenida ...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2008
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-08-0020